EVALUATION OF CD82/ (KAI-1) IMMUNOHISTOCHEMICAL EXPRESSION IN COLORECTAL CARCINOMA

نویسندگان

چکیده

Background: Colorectal carcinoma (CRC) is one of the most common human cancers. It fourth cause death from cancer. cancer third in men and second women worldwide. Objective: To evaluate immunohistochemical expression KAI-1/CD82 different stages colorectal to biological behavior tumor target therapy. Patients Methods: Thirty formalin-fixed, paraffin-embedded tissue (obtained archive Al-Azhar University Hospital Labs some private labs). Clinicopathological histological features were taken files confirmed by H&E examination. Immunohistochemical study was done using CD82/ (KAI-1) marker. Results: CD82 showed an insignificant relation with age, sex, site degree differentiation. A significant inverse relationship detected between cells stage according modified Duke's staging. Insignificant grade. Conclusion: The decreased membranous and/or cytoplasmic might be used as a prognostic marker monitor patient

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Histopathological Evaluation and Analysis of Immunohistochemical Expression of Bcl-2 Oncoprotein in Colorectal Carcinoma

Abstract Introduction: Colorectal cancer is the third most prevalent malignancy with high mortality rate, necessitating markers that predict survival and guide the treatment. Previous studies have examined the immunohistochemical expression of Bcl-2, an apoptotic marker, in colorectal carcinoma, but results have been contradictory. Objectives: To evaluate the histopathological featu...

متن کامل

Immunohistochemical Expression of HER2/neu in Colorectal Carcinoma

Colorectal carcinoma ranks fourth among the most common leading causes of cancer-related mortality in the world. Her2/neu oncogen is one of four epidermal growth factor receptors. It's located on chromosome 17q21 and encodes a 185 transmembrane protein with tyrosine kinase activity that functions as a growth factor receptor. Clinically, amplification and/or overexpression of Her2/neu has been a...

متن کامل

Immunohistochemical Evaluation of Fascin in Oral Squamous Cell Carcinoma

Background and purpose: Squamous cell carcinoma (SCC) is the eighth most common cancer in men and the fifteenth in women. Localized recurrence and metastasis to regional lymph nodes are major problems in these patients. Fascin is a 55- kDa protein from the family of actin-binding proteins that is expressed in cells with membranous bronchial tubes. The aim of this study was to evaluate the expre...

متن کامل

Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1

The 'metastasis suppressor' CD82/KAI-1, a member of the tetraspanin superfamily of transmembrane proteins, is widely distributed in normal tissues [1], and has been shown to be suppressed in the advanced stages of various epithelial malignancies [2-6]. Although the physiological relevance of this change is unknown, in vitro data show that ectopically expressed CD82/KAI-1 can suppress tumor cell...

متن کامل

Immunohistochemical Expression of p53 and bcl2 in Colorectal Adenomas and Carcinomas Using Automated Cellular Imaging System

Background & Objective: The current approaches to reduce the risk of colorectal carcinoma are through the detection and removal of the precursor lesion” adenomatous polyps”. The study was conducted to evaluate the immunohistochemical expression of p53 and bcl2 in colorectal adenomas and carcinomas. Patients and Methods: A total of 86 cases, 33 colorectal adenomas, 33 colorect...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Al-Azhar Medical Journal

سال: 2021

ISSN: ['1110-0400']

DOI: https://doi.org/10.21608/amj.2021.158642